Apr 16,2021

Novel stem cell therapy for repair of knee cartila

Recycling patient cells


Existing cell therapy to repair knee cartilage generally involves surgically debriding the cartilage defect and then taking a biopsy of healthy cartilage from the patient. The biopsy is cultured in an outside laboratory, and the cultured cells are implanted weeks later. "We wanted to improve this technique because during the waiting period, the patient's life is on hold, costs increase and the logistics can be complex," Dr. Saris says.



膝关节健康



RECLAIM's innovation starts with saving the patient's debrided tissue. "That tissue is always a bit frilly and is normally discarded," Dr. Saris says. "But we found that the cells in that tissue are still very viable. We recycle them."



二、给关节补充



The resected tissue is processed and, using a rapid isolation protocol, digested into chondrons. Mixing the chondrons with allogeneic stem cells from the stem cell bank provides sufficient cells to immediately re-inject into the patient.

"This is a highly innovative procedure," Dr. Saris says. "You have to find an intricate balance — loading enough cells to grow into healthy tissue but not overloading the space so the cells are squished when the patient starts rehab."



首届嵩山骨科高峰论坛召开 力达康推2项关节医疗技术



Most patients return home on the day of surgery. They generally need to wait nine to 12 months before a full return to sports; that interval provides time for the cartilage to grow and the patient to regain muscle control. "But apart from sports, patients can go back to normal life within days and physical activities within three to four months of surgery," Dr. Saris says.



软骨组织新陈代谢本身速度非常缓慢。


Mayo Clinic's multidisciplinary approach provides the range of care needed by patients at all stages of knee cartilage repair. Before surgery, advanced imaging helps pinpoint the cartilage defect. "Our physiotherapists and athletic trainers also determine prior to surgery how we can optimize the patient's musculoskeletal control and function, and then work with the patient on rehab after surgery," Dr. Saris says.


5、普拉提   普拉提主要是锻炼肌肉为主,在主要运动锻炼中,应该以腹部锻炼为主,加强腹部锻炼腹直肌的锻炼,有利于分娩后,腹直肌肉的锻烈,另外在普拉提的运动里,也可以增强体力和肌肉的张力,增强身体平衡,刺激腺体分泌激素。



Mayo Clinic also has the breadth of orthopedic expertise to manage problems that patients often experience alongside damaged knee cartilage, such as varus deformity and anterior cruciate ligament or meniscus lesions. "If a cartilage repair procedure fails, it's generally because not enough attention was paid to other factors — the meniscus or the knee's alignment or stability," Dr. Saris says. "Our unique multidisciplinary team looks at all aspects of a patient's care. Our chances of success for these complex biological reconstructions is therefore high."



干细胞到底是什么 科学家称任何细胞都可以是干细胞


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